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Ultra-specific discrimination of single-nucleotide mutations using sequestration-assisted molecular beacons
Reliably distinguishing single-nucleotide mutations (SNMs) at low abundance is of great significance in clinical diagnosis. However, the specificity of most current SNM discrimination methods based on the Watson–Crick hybridization is seriously limited by the cross-reactivity of the probe with close...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356502/ https://www.ncbi.nlm.nih.gov/pubmed/28451240 http://dx.doi.org/10.1039/c6sc03048c |