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DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically

Gastric cancer (GC) is among the most malignant cancers with high incidence and poor prognoses worldwide as well as in China. dCTP pyrophosphatase 1 (DCTPP1) is overexpressed in GC with a poor prognosis. Given chemotherapeutic drugs share similar structures with pyrimidine nucleotides, the role of D...

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Detalles Bibliográficos
Autores principales: Xia, Li-liang, Tang, Ya-bin, Song, Fei-fei, Xu, Ling, Ji, Ping, Wang, Shu-jun, Zhu, Ji-min, Zhang, Yong, Zhao, Guo-ping, Wang, Ying, Liu, Tao-tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356578/
https://www.ncbi.nlm.nih.gov/pubmed/27612427
http://dx.doi.org/10.18632/oncotarget.11864