Heterozygous mutation of cysteine(528) in XPO1 is sufficient for resistance to selective inhibitors of nuclear export

Exportin-1 (CRM1/XPO1) is a crucial nuclear export protein that transports a wide variety of proteins from the nucleus to the cytoplasm. These cargo proteins include tumor suppressors and growth-regulatory factors and as such XPO1 is considered a potential anti-cancer target. From this perspective,...

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Detalles Bibliográficos
Autores principales: Neggers, Jasper Edgar, Vanstreels, Els, Baloglu, Erkan, Shacham, Sharon, Landesman, Yosef, Daelemans, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356594/
https://www.ncbi.nlm.nih.gov/pubmed/27634897
http://dx.doi.org/10.18632/oncotarget.11995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356594/
https://www.ncbi.nlm.nih.gov/pubmed/27634897
http://dx.doi.org/10.18632/oncotarget.11995

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