WW45, a Gli1 binding protein, negatively regulated Hedgehog signaling in lung cancer

Over-expression of Gli1 is very common in lung cancer. However, the underlying molecular mechanism remains largely unknown. Here, using mass spectrum, we have identified WW45 as a binding partner of Gli1. WW45 interacted with Gli1, promoted its ubiquitination and inhibited the expression of its targ...

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Detalles Bibliográficos
Autores principales: Li, Xuebing, Zhou, Xuexia, Fan, Yaguang, Zhang, Yalong, Zu, Lingling, Yao, Feng, Zhou, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356604/
https://www.ncbi.nlm.nih.gov/pubmed/27661123
http://dx.doi.org/10.18632/oncotarget.12155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356604/
https://www.ncbi.nlm.nih.gov/pubmed/27661123
http://dx.doi.org/10.18632/oncotarget.12155

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