E-cadherin downregulation sensitizes PTEN-mutant tumors to PI3Kβ silencing

Alterations in phosphatidylinositol 3-kinase (PI3K) and in PTEN (phosphatase and tensin homolog), the negative regulator of the PI3K pathway, are found in nearly half of human tumors. As PI3Kβ, the main isoform activated in PTEN-mutant tumors, has kinase-dependent and -independent activities, we com...

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Detalles Bibliográficos
Autores principales: Millán-Uclés, África, Zuluaga, Susana, Marqués, Miriam, Vallejo-Díaz, Jesus, Sanz, Lorena, Cariaga-Martínez, Ariel E, Real, Francisco X, Carrera, Ana C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356644/
https://www.ncbi.nlm.nih.gov/pubmed/27863432
http://dx.doi.org/10.18632/oncotarget.13414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356644/
https://www.ncbi.nlm.nih.gov/pubmed/27863432
http://dx.doi.org/10.18632/oncotarget.13414

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