Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C

Nf1 mutations or deletions are suggested to underlie the tumor predisposition of NF1 (neurofibromatosis type 1) and few treatments are available for treating NF1 patients with advanced malignant tumors. Aberrant activation of Ras in Nf1-deficient conditions is responsible for the promotion of tumori...

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Detalles Bibliográficos
Autores principales: Ganapathy, Suthakar, Fagman, Johan B, Shen, Ling, Yu, Tianqi, Zhou, Xiaodong, Dai, Wei, Makriyannis, Alexandros, Chen, Changyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356664/
https://www.ncbi.nlm.nih.gov/pubmed/27741517
http://dx.doi.org/10.18632/oncotarget.12607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356664/
https://www.ncbi.nlm.nih.gov/pubmed/27741517
http://dx.doi.org/10.18632/oncotarget.12607

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