FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma

FOXC1 is a member of Forkhead box family transcription factors. We showed that FOXC1 level was increased in melanoma cells and tissues and correlated with hypomethylation of the FOXC1 gene. Overexpression of FOXC1 promoted proliferation, migration, invasion, colony formation and growth in 3D Matrige...

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Detalles Bibliográficos
Autores principales: Wang, Jinhua, Li, Li, Liu, Shiwei, Zhao, Ying, Wang, Lin, Du, Guanhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356666/
https://www.ncbi.nlm.nih.gov/pubmed/27533251
http://dx.doi.org/10.18632/oncotarget.11224
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author Wang, Jinhua
Li, Li
Liu, Shiwei
Zhao, Ying
Wang, Lin
Du, Guanhua
author_facet Wang, Jinhua
Li, Li
Liu, Shiwei
Zhao, Ying
Wang, Lin
Du, Guanhua
author_sort Wang, Jinhua
collection PubMed
description FOXC1 is a member of Forkhead box family transcription factors. We showed that FOXC1 level was increased in melanoma cells and tissues and correlated with hypomethylation of the FOXC1 gene. Overexpression of FOXC1 promoted proliferation, migration, invasion, colony formation and growth in 3D Matrigel of melanoma cells. FOXC1 increased MST1R and activated the PI3K/AKT pathway. Also, FOXC1 expression was associated with disease progression and poor prognosis of melanoma. We suggest that FOXC1 is a potential prognostic biomarker for treating melanoma and predicting outcome of patients.
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spelling pubmed-53566662017-04-26 FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma Wang, Jinhua Li, Li Liu, Shiwei Zhao, Ying Wang, Lin Du, Guanhua Oncotarget Research Paper FOXC1 is a member of Forkhead box family transcription factors. We showed that FOXC1 level was increased in melanoma cells and tissues and correlated with hypomethylation of the FOXC1 gene. Overexpression of FOXC1 promoted proliferation, migration, invasion, colony formation and growth in 3D Matrigel of melanoma cells. FOXC1 increased MST1R and activated the PI3K/AKT pathway. Also, FOXC1 expression was associated with disease progression and poor prognosis of melanoma. We suggest that FOXC1 is a potential prognostic biomarker for treating melanoma and predicting outcome of patients. Impact Journals LLC 2016-08-11 /pmc/articles/PMC5356666/ /pubmed/27533251 http://dx.doi.org/10.18632/oncotarget.11224 Text en Copyright: © 2016 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Jinhua
Li, Li
Liu, Shiwei
Zhao, Ying
Wang, Lin
Du, Guanhua
FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma
title FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma
title_full FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma
title_fullStr FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma
title_full_unstemmed FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma
title_short FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway and is associated with poor prognosis in melanoma
title_sort foxc1 promotes melanoma by activating mst1r/pi3k/akt pathway and is associated with poor prognosis in melanoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356666/
https://www.ncbi.nlm.nih.gov/pubmed/27533251
http://dx.doi.org/10.18632/oncotarget.11224
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