Human sulfatase 1 exerts anti-tumor activity by inhibiting the AKT/ CDK4 signaling pathway in melanoma

Human sulfatase 1 (hSulf-1) has aryl sulfatase activity. It can reduce the sulfation of cell surface heparan sulfate proteoglycan (HSPG) and inhibit various growth factor receptor-mediated signaling pathways. In most cancers, hSulf-1 is inactivated, which endows cancer cells with increasesed cell pr...

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Detalles Bibliográficos
Autores principales: Lou, Xiaoli, Sun, Bin, Song, Jianxing, Wang, Yicun, Jiang, Junhao, Xu, Yang, Ren, Zeqiang, Su, Changqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356675/
https://www.ncbi.nlm.nih.gov/pubmed/27806323
http://dx.doi.org/10.18632/oncotarget.12996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356675/
https://www.ncbi.nlm.nih.gov/pubmed/27806323
http://dx.doi.org/10.18632/oncotarget.12996

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