p16(INK4a) suppresses BRCA1-deficient mammary tumorigenesis

Senescence prevents the proliferation of genomically damaged, but otherwise replication competent cells at risk of neoplastic transformation. p16(INK4A) (p16), an inhibitor of CDK4 and CDK6, plays a critical role in controlling cellular senescence in multiple organs. Functional inactivation of p16 b...

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Detalles Bibliográficos
Autores principales: Scott, Alexandria, Bai, Feng, Chan, Ho Lam, Liu, Shiqin, Ma, Jinshan, Slingerland, Joyce M, Robbins, David J., Capobianco, Anthony J., Pei, Xin-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356676/
https://www.ncbi.nlm.nih.gov/pubmed/27811360
http://dx.doi.org/10.18632/oncotarget.13015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356676/
https://www.ncbi.nlm.nih.gov/pubmed/27811360
http://dx.doi.org/10.18632/oncotarget.13015

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