Cargando…

p16(INK4a) suppresses BRCA1-deficient mammary tumorigenesis

Senescence prevents the proliferation of genomically damaged, but otherwise replication competent cells at risk of neoplastic transformation. p16(INK4A) (p16), an inhibitor of CDK4 and CDK6, plays a critical role in controlling cellular senescence in multiple organs. Functional inactivation of p16 b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scott, Alexandria, Bai, Feng, Chan, Ho Lam, Liu, Shiqin, Ma, Jinshan, Slingerland, Joyce M, Robbins, David J., Capobianco, Anthony J., Pei, Xin-Hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356676/ https://www.ncbi.nlm.nih.gov/pubmed/27811360 http://dx.doi.org/10.18632/oncotarget.13015

Ejemplares similares

Gata3 restrains B cell proliferation and cooperates with p18(INK4c) to repress B cell lymphomagenesis
por: Liu, Shiqin, et al.
Publicado: (2016)

PDGFRβ is an essential therapeutic target for BRCA1-deficient mammary tumors
por: Bai, Feng, et al.
Publicado: (2021)

PTEN deficiency: a role in mammary carcinogenesis
por: Petrocelli, Teresa, et al.
Publicado: (2001)

Loss of function of GATA3 induces basal-like mammary tumors
por: Bai, Feng, et al.
Publicado: (2022)

Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing
por: Sun, Heng, et al.
Publicado: (2021)

Roles of BCCIP deficiency in mammary tumorigenesis
por: Droz-Rosario, Roberto, et al.
Publicado: (2017)

Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression
por: Wang, Chuying, et al.
Publicado: (2018)

Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway
por: Bai, Feng, et al.
Publicado: (2022)

Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy
por: Lei, Josh Haipeng, et al.
Publicado: (2021)

Stimulation of epidermal hyperplasia and tumorigenesis by resident p16(INK4a)-expressing cells
por: Azazmeh, Narmen, et al.
Publicado: (2020)

Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
por: Chang, Zhe, et al.
Publicado: (2014)

CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16(INK4a)
por: Du, Wenqi, et al.
Publicado: (2019)

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation
por: Liu, Jing, et al.
Publicado: (2013)

G-Quadruplex Matters in Tissue-Specific Tumorigenesis by BRCA1 Deficiency
por: Kim, Sanghyun, et al.
Publicado: (2022)

Sustained p16(INK4a) expression is required to prevent IR-induced tumorigenesis in mice
por: Palacio, L, et al.
Publicado: (2016)

CtBP1 is expressed in melanoma and represses the transcription of p16INK4a and Brca1
por: Deng, Hui, et al.
Publicado: (2013)

Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16(INK4a) deficiency and telomere-dependent genotoxic stress
por: Domínguez, Daniel, et al.
Publicado: (2015)

Loss of function of GATA3 regulates FRA1 and c-FOS to activate EMT and promote mammary tumorigenesis and metastasis
por: Liu, Xiong, et al.
Publicado: (2023)

BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)
por: Chen, Qiang, et al.
Publicado: (2020)

Gpr177 Deficiency Impairs Mammary Development and Prohibits Wnt-Induced Tumorigenesis
por: Maruyama, Eri Ohfuchi, et al.
Publicado: (2013)

Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
Publicado: (2019)

Sox11 regulates mammary tumour-initiating and metastatic capacity in Brca1-deficient mouse mammary tumour cells
por: Tsang, Siu Man, et al.
Publicado: (2021)

Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cells
por: Alli, Elizabeth, et al.
Publicado: (2011)

BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis
por: Chen, Qiang, et al.
Publicado: (2020)

TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway
por: Su, X, et al.
Publicado: (2017)

Low frequency of p16(INK4a) promoter methylation in mammary carcinomas as revealed by positive display of methylated sites
por: Lilischkis, R, et al.
Publicado: (2000)

The Pathology of EMT in Mouse Mammary Tumorigenesis
por: Cardiff, Robert Darrell
Publicado: (2010)

brca2 and tp53 Collaborate in Tumorigenesis in Zebrafish
por: Shive, Heather R., et al.
Publicado: (2014)

ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis
por: Campbell, Craig I, et al.
Publicado: (2010)

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors
por: Bhin, Jinhyuk, et al.
Publicado: (2023)

p16(INK4a) Translation Suppressed by miR-24
por: Lal, Ashish, et al.
Publicado: (2008)

Over-expression of ST3Gal-I promotes mammary tumorigenesis
por: Picco, Gianfranco, et al.
Publicado: (2010)

NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis
por: Shersher, Elena, et al.
Publicado: (2021)

Bone Marrow p16(INK4a)-Deficiency Does Not Modulate Obesity, Glucose Homeostasis or Atherosclerosis Development
por: Wouters, Kristiaan, et al.
Publicado: (2012)

Effect of constant light on DMBA mammary tumorigenesis in rats
por: Anderson, L.E., et al.
Publicado: (2000)

Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors
por: Baek, Hye Jung, et al.
Publicado: (2018)

Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development
por: Huo, Yanying, et al.
Publicado: (2021)

Genetic Mechanisms in Apc-Mediated Mammary Tumorigenesis
por: Kuraguchi, Mari, et al.
Publicado: (2009)

In utero alcohol exposure increases mammary tumorigenesis in rats
por: Hilakivi-Clarke, L, et al.
Publicado: (2004)

Brca1 (L63X) (/+) rat is a novel model of human BRCA1 deficiency displaying susceptibility to radiation‐induced mammary cancer
por: Nakamura, Yuzuki, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3pq3ed67a5pgd2r27lbc8p5j6t