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Different BCR/Abl protein suppression patterns as a converging trait of chronic myeloid leukemia cell adaptation to energy restriction

BCR/Abl protein drives the onset and progression of Chronic Myeloid Leukemia (CML). We previously showed that BCR/Abl protein is suppressed in low oxygen, where viable cells retain stem cell potential. This study addressed the regulation of BCR/Abl protein expression under oxygen or glucose shortage...

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Detalles Bibliográficos
Autores principales: Bono, Silvia, Lulli, Matteo, D'Agostino, Vito Giuseppe, Gesualdo, Federico Di, Loffredo, Rosa, Cipolleschi, Maria Grazia, Provenzani, Alessandro, Rovida, Elisabetta, Sbarba, Persio Dello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356700/
https://www.ncbi.nlm.nih.gov/pubmed/27852045
http://dx.doi.org/10.18632/oncotarget.13319