Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma

Oncogenic mutations in the PI3K/AKT pathway are present in nearly half of human tumors. Nonetheless, inhibitory compounds of the pathway often induce pathway rebound and tumor resistance. We find that lung squamous cell carcinoma (SQCC), which accounts for ~20% of lung cancer, exhibits increased exp...

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Detalles Bibliográficos
Autores principales: Vallejo-Díaz, Jesús, Olazabal-Morán, Manuel, Cariaga-Martínez, Ariel E., Pajares, María J., Flores, Juana M., Pio, Ruben, Montuenga, Luis M., Carrera, Ana Clara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356720/
https://www.ncbi.nlm.nih.gov/pubmed/27835880
http://dx.doi.org/10.18632/oncotarget.13195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356720/
https://www.ncbi.nlm.nih.gov/pubmed/27835880
http://dx.doi.org/10.18632/oncotarget.13195

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