Cargando…

Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma

Oncogenic mutations in the PI3K/AKT pathway are present in nearly half of human tumors. Nonetheless, inhibitory compounds of the pathway often induce pathway rebound and tumor resistance. We find that lung squamous cell carcinoma (SQCC), which accounts for ~20% of lung cancer, exhibits increased exp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vallejo-Díaz, Jesús, Olazabal-Morán, Manuel, Cariaga-Martínez, Ariel E., Pajares, María J., Flores, Juana M., Pio, Ruben, Montuenga, Luis M., Carrera, Ana Clara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356720/ https://www.ncbi.nlm.nih.gov/pubmed/27835880 http://dx.doi.org/10.18632/oncotarget.13195

Ejemplares similares

TGFBI expression is an independent predictor of survival in adjuvant-treated lung squamous cell carcinoma patients
por: Pajares, M J, et al.
Publicado: (2014)

E-cadherin downregulation sensitizes PTEN-mutant tumors to PI3Kβ silencing
por: Millán-Uclés, África, et al.
Publicado: (2016)

Overexpression of TMPRSS4 in non-small cell lung cancer is associated with poor prognosis in patients with squamous histology
por: Larzabal, L, et al.
Publicado: (2011)

Contrasting responses of non-small cell lung cancer to antiangiogenic therapies depend on histological subtype
por: Larrayoz, Marta, et al.
Publicado: (2014)

Epigenetic alterations leading to TMPRSS4 promoter hypomethylation and protein overexpression predict poor prognosis in squamous lung cancer patients
por: Villalba, Maria, et al.
Publicado: (2016)

Identification of Novel Deregulated RNA Metabolism-Related Genes in Non-Small Cell Lung Cancer
por: Valles, Iñaki, et al.
Publicado: (2012)

Phosphoinositide 3-kinase p85beta regulates invadopodium formation
por: Cariaga-Martínez, Ariel E., et al.
Publicado: (2014)

The Vast Complexity of the Epigenetic Landscape during Neurodevelopment: An Open Frame to Understanding Brain Function
por: Cariaga-Martínez, Ariel Ernesto, et al.
Publicado: (2018)

Expression of Sirtuin 1 and 2 Is Associated with Poor Prognosis in Non-Small Cell Lung Cancer Patients
por: Grbesa, Ivana, et al.
Publicado: (2015)

Transient T cell depletion causes regression of melanoma metastases
por: Rasku, Mary Ann, et al.
Publicado: (2008)

Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia
por: Cariaga-Martinez, Ariel, et al.
Publicado: (2017)

Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL
por: Olazábal-Morán, Manuel, et al.
Publicado: (2021)

The Role of PIK3R1 in Metabolic Function and Insulin Sensitivity
por: Tsay, Ariel, et al.
Publicado: (2023)

KRAS, BRAF and PIK3CA Status in Squamous Cell Anal Carcinoma (SCAC)
por: Casadei Gardini, Andrea, et al.
Publicado: (2014)

PIK3CA gene mutations in Northwest Chinese esophageal squamous cell carcinoma
por: Liu, Shi-Yuan, et al.
Publicado: (2017)

Identification of Importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens
por: Nguewa, Paul A, et al.
Publicado: (2008)

From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia
por: Cariaga-Martinez, Ariel, et al.
Publicado: (2016)

The Differential Impact of SRC Expression on the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma
por: Hermida-Prado, Francisco, et al.
Publicado: (2019)

The sVEGFR1-i13 splice variant regulates a β1 integrin/VEGFR autocrine loop involved in the progression and the response to anti-angiogenic therapies of squamous cell lung carcinoma
por: Abou Faycal, Cherine, et al.
Publicado: (2018)

Immune Cell Infiltrates and Neutrophil-to-Lymphocyte Ratio in Relation to Response to Chemotherapy and Prognosis in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas
por: Sánchez-Canteli, Mario, et al.
Publicado: (2021)

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma
por: Chiosea, Simion I, et al.
Publicado: (2013)

Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance
por: Zainal, Nur Syafinaz, et al.
Publicado: (2019)

Any Role of PIK3CA and PTEN Biomarkers in the Prognosis in Oral Squamous Cell Carcinoma?
por: Starzyńska, Anna, et al.
Publicado: (2020)

Complement activation mediates cetuximab inhibition of non-small cell lung cancer tumor growth in vivo
por: Hsu, Yi-Fan, et al.
Publicado: (2010)

Complement C4d-specific antibodies for the diagnosis of lung cancer
por: Ajona, Daniel, et al.
Publicado: (2017)

Simultaneous Assessment of Rotavirus-Specific Memory B Cells and Serological Memory after B Cell Depletion Therapy with Rituximab
por: Herrera, Daniel, et al.
Publicado: (2014)

Smokers with CT Detected Emphysema and No Airway Obstruction Have Decreased Plasma Levels of EGF, IL-15, IL-8 and IL-1ra
por: de-Torres, Juan P., et al.
Publicado: (2013)

Elevated Levels of the Complement Activation Product C4d in Bronchial Fluids for the Diagnosis of Lung Cancer
por: Ajona, Daniel, et al.
Publicado: (2015)

Prognostic significance of PIK3CA and SOX2 in Asian patients with lung squamous cell carcinoma
por: IIJIMA, YOSHIHITO, et al.
Publicado: (2014)

Carcinogenesis of PIK3CA
por: German, Sidra, et al.
Publicado: (2013)

EventPointer: an effective identification of alternative splicing events using junction arrays
por: Romero, Juan P., et al.
Publicado: (2016)

Evaluation of PIK3CA mutations in advanced ER+/HER2-breast cancer in Portugal – U-PIK Project
por: Peixoto, Ana, et al.
Publicado: (2023)

TMPRSS4: A Novel Tumor Prognostic Indicator for the Stratification of Stage IA Tumors and a Liquid Biopsy Biomarker for NSCLC Patients
por: Villalba, Maria, et al.
Publicado: (2019)

Diagnostico para la acreditación del laboratorio de química de la facultad de ciencias químicas de Poza Rica, Ver. /
por: Solorzano Cariaga, Lopolda
Publicado: (1999)

Two cell line models to study multiorganic metastasis and immunotherapy in lung squamous cell carcinoma
por: Valencia, Karmele, et al.
Publicado: (2022)

Development of a novel splice array platform and its application in the identification of alternative splice variants in lung cancer
por: Pio, Ruben, et al.
Publicado: (2010)

Tumor-Intrinsic Nuclear β-Catenin Associates with an Immune Ignorance Phenotype and a Poorer Prognosis in Head and Neck Squamous Cell Carcinomas
por: Sánchez-Canteli, Mario, et al.
Publicado: (2022)

4373 Defining the role of non-canonical PIK3CA mutations in head and neck squamous cell carcinoma
por: Lee, Michelle Ji-Eun, et al.
Publicado: (2020)

Prognostic value of the PIK3CA, AKT, and PTEN mutations in oral squamous cell carcinoma: literature review
por: Starzyńska, Anna, et al.
Publicado: (2020)

Frequency of PIK3CA mutations in different subsites of head and neck squamous cell carcinoma in southern Thailand
por: Dechaphunkul, Arunee, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pvqfbtpb3bcm7t991rth1l31fs