TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress

Tuberous Sclerosis (TSC) is characterized by exorbitant mTORC1 signalling and manifests as non-malignant, apoptosis-prone neoplasia. Previous reports have shown that TSC(-/-) cells are highly susceptible to mild, innocuous doses of genotoxic stress, which drive TSC(-/-) cells into apoptotic death. I...

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Detalles Bibliográficos
Autores principales: Pai, Govind M., Zielinski, Alexandra, Koalick, Dennis, Ludwig, Kristin, Wang, Zhao-Qi, Borgmann, Kerstin, Pospiech, Helmut, Rubio, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356742/
https://www.ncbi.nlm.nih.gov/pubmed/27863419
http://dx.doi.org/10.18632/oncotarget.13378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356742/
https://www.ncbi.nlm.nih.gov/pubmed/27863419
http://dx.doi.org/10.18632/oncotarget.13378

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