Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption

Chemoresistance represents a major challenge for treatment of acute lymphoblastic leukemia (ALL). Thus, new drugs to overcome chemoresistance in ALL are urgently needed. To this end, we established a cytarabine (araC)-resistant ALL cell line (NALM-6/R), which interestingly displayed cross-resistance...

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Detalles Bibliográficos
Autores principales: Zhao, Haijun, Shi, Pengcheng, Deng, Manman, Jiang, Zhiwu, Li, Yin, Kannappan, Vinodh, Wang, Weiguang, Li, Peng, Xu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356754/
https://www.ncbi.nlm.nih.gov/pubmed/27888802
http://dx.doi.org/10.18632/oncotarget.13454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356754/
https://www.ncbi.nlm.nih.gov/pubmed/27888802
http://dx.doi.org/10.18632/oncotarget.13454

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