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ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation
Given that mutated p53 (50% of all human cancers) is over-expressed in many cancers, restoration of mutant p53 to its wild type biological function has been sought after as cancer therapy. The conformational flexibility has allowed to restore the normal biological function of mutant p53 by short pep...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356822/ https://www.ncbi.nlm.nih.gov/pubmed/27911860 http://dx.doi.org/10.18632/oncotarget.13701 |