Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner

Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma. Herein we demonstrated that the TKI axitinib induces DN...

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Detalles Bibliográficos
Autores principales: Morelli, Maria Beatrice, Amantini, Consuelo, Nabissi, Massimo, Cardinali, Claudio, Santoni, Matteo, Bernardini, Giovanni, Santoni, Angela, Santoni, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356889/
https://www.ncbi.nlm.nih.gov/pubmed/27926485
http://dx.doi.org/10.18632/oncotarget.13769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356889/
https://www.ncbi.nlm.nih.gov/pubmed/27926485
http://dx.doi.org/10.18632/oncotarget.13769

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