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Early and Late Pathomechanisms in Alzheimer’s Disease: From Zinc to Amyloid-β Neurotoxicity

There are several systemic and intracerebral pathologic conditions, which limit provision and utilization of energy precursor metabolites in neuronal cells. Energy deficits cause excessive depolarization of neuronal cells triggering glutamate-zinc evoked excitotoxic cascade. The intracellular zinc e...

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Detalles Bibliográficos
Autores principales: Szutowicz, Andrzej, Bielarczyk, Hanna, Zyśk, Marlena, Dyś, Aleksandra, Ronowska, Anna, Gul-Hinc, Sylwia, Klimaszewska-Łata, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357490/
https://www.ncbi.nlm.nih.gov/pubmed/28039593
http://dx.doi.org/10.1007/s11064-016-2154-z