Off-Target Anti-Inflammatory Activity of the P2X7 Receptor Antagonist AZ11645373

We have found that a well-characterized P2X7 receptor antagonist AZ11645373 blocked production of pro-inflammatory chemokine IL-8 in endothelial cells treated with OxPAPC. The effect was not due to toxicity of AZ11645373 as documented by cellular metabolic activity assay. The mechanism of inhibition...

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Detalles Bibliográficos
Autores principales: Oskolkova, Olga V., Godschachner, Viktoria, Bochkov, Valery N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357502/
https://www.ncbi.nlm.nih.gov/pubmed/28101847
http://dx.doi.org/10.1007/s10753-016-0499-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357502/
https://www.ncbi.nlm.nih.gov/pubmed/28101847
http://dx.doi.org/10.1007/s10753-016-0499-8

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