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A method for identifying genetic heterogeneity within phenotypically-defined disease subgroups

Many common diseases show wide phenotypic variation. We present a statistical method for determining whether phenotypically defined subgroups of disease cases represent different genetic architectures, in which disease-associated variants have different effect sizes in the two subgroups. Our method...

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Detalles Bibliográficos
Autores principales: Liley, James, Todd, John A, Wallace, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357574/
https://www.ncbi.nlm.nih.gov/pubmed/28024155
http://dx.doi.org/10.1038/ng.3751