Cargando…
A method for identifying genetic heterogeneity within phenotypically-defined disease subgroups
Many common diseases show wide phenotypic variation. We present a statistical method for determining whether phenotypically defined subgroups of disease cases represent different genetic architectures, in which disease-associated variants have different effect sizes in the two subgroups. Our method...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357574/ https://www.ncbi.nlm.nih.gov/pubmed/28024155 http://dx.doi.org/10.1038/ng.3751 |