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A method for identifying genetic heterogeneity within phenotypically-defined disease subgroups
Many common diseases show wide phenotypic variation. We present a statistical method for determining whether phenotypically defined subgroups of disease cases represent different genetic architectures, in which disease-associated variants have different effect sizes in the two subgroups. Our method...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357574/ https://www.ncbi.nlm.nih.gov/pubmed/28024155 http://dx.doi.org/10.1038/ng.3751 |