Cargando…
Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling
The thymus is the major site for normal and leukemic T-cell development. The dissection of the molecular determinants of T-cell survival and differentiation is paramount for the manipulation of healthy or transformed T cells in cancer (immuno)therapy. Casein kinase 2 (CK2) is a serine/threonine prot...
Autores principales: | Ribeiro, S T, Tesio, M, Ribot, J C, Macintyre, E, Barata, J T, Silva-Santos, B |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357576/ https://www.ncbi.nlm.nih.gov/pubmed/27899804 http://dx.doi.org/10.1038/leu.2016.363 |
Ejemplares similares
-
TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets
por: Muñoz-Ruiz, Miguel, et al.
Publicado: (2016) -
Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells
por: Sumaria, Nital, et al.
Publicado: (2017) -
Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation
por: Ribeiro, Sérgio T., et al.
Publicado: (2015) -
Improved Survival of Leukemic Mice Treated with Sodium Caseinate in Combination with Daunorubicin without Toxicity
por: Aguiñiga-Sánchez, Itzen, et al.
Publicado: (2021) -
Thymic Program Directing the Functional Development of γδT17 Cells
por: Jouan, Youenn, et al.
Publicado: (2018)