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The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling Modules
The prion glycoprotein (PrP(C)) is mostly located at the cell surface, tethered to the plasma membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrP(C) is associated with the transmissible spongiform encephalopathies (TSEs), whereas its normal conformer serves as a recepto...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357658/ https://www.ncbi.nlm.nih.gov/pubmed/28373833 http://dx.doi.org/10.3389/fnmol.2017.00077 |