Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1

Dbf4-dependent kinases (DDKs) are required for the initiation of DNA replication, their essential targets being the MCM2-7 proteins. We show that, in Xenopus laevis egg extracts and human cells, hyper-phosphorylation of DNA-bound Mcm4, but not phosphorylation of Mcm2, correlates with DNA replication...

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Detalles Bibliográficos
Autores principales: Alver, Robert C., Chadha, Gaganmeet Singh, Gillespie, Peter J., Blow, J. Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357733/
https://www.ncbi.nlm.nih.gov/pubmed/28273463
http://dx.doi.org/10.1016/j.celrep.2017.02.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357733/
https://www.ncbi.nlm.nih.gov/pubmed/28273463
http://dx.doi.org/10.1016/j.celrep.2017.02.042

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