Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway

Cellular senescence is an important in vivo mechanism that prevents the propagation of damaged cells. However, the precise mechanisms regulating senescence are not well characterized. Here, we find that ITGB3 (integrin beta 3 or β3) is regulated by the Polycomb protein CBX7. β3 expression accelerate...

Descripción completa

Detalles Bibliográficos
Autores principales: Rapisarda, Valentina, Borghesan, Michela, Miguela, Veronica, Encheva, Vesela, Snijders, Ambrosius P., Lujambio, Amaia, O’Loghlen, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357738/
https://www.ncbi.nlm.nih.gov/pubmed/28273461
http://dx.doi.org/10.1016/j.celrep.2017.02.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357738/
https://www.ncbi.nlm.nih.gov/pubmed/28273461
http://dx.doi.org/10.1016/j.celrep.2017.02.012

Ejemplares similares