Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening

The natural product mangiferin (compound 7) has been identified as a potential glucokinase activator by structure-based virtual ligand screening. It was proved by enzyme activation experiment and cell-based assays in vitro, with potency in micromolar range. Meanwhile, this compound showed good antih...

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Detalles Bibliográficos
Autores principales: Min, Qiuxia, Cai, Xinpei, Sun, Weiguang, gao, Fei, Li, Zhimei, Zhang, Qian, Wan, Luo-Sheng, Li, Hua, Chen, Jiachun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357792/
https://www.ncbi.nlm.nih.gov/pubmed/28317897
http://dx.doi.org/10.1038/srep44681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357792/
https://www.ncbi.nlm.nih.gov/pubmed/28317897
http://dx.doi.org/10.1038/srep44681

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