Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening

The natural product mangiferin (compound 7) has been identified as a potential glucokinase activator by structure-based virtual ligand screening. It was proved by enzyme activation experiment and cell-based assays in vitro, with potency in micromolar range. Meanwhile, this compound showed good antih...

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Autores principales: Min, Qiuxia, Cai, Xinpei, Sun, Weiguang, gao, Fei, Li, Zhimei, Zhang, Qian, Wan, Luo-Sheng, Li, Hua, Chen, Jiachun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357792/
https://www.ncbi.nlm.nih.gov/pubmed/28317897
http://dx.doi.org/10.1038/srep44681
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author Min, Qiuxia
Cai, Xinpei
Sun, Weiguang
gao, Fei
Li, Zhimei
Zhang, Qian
Wan, Luo-Sheng
Li, Hua
Chen, Jiachun
author_facet Min, Qiuxia
Cai, Xinpei
Sun, Weiguang
gao, Fei
Li, Zhimei
Zhang, Qian
Wan, Luo-Sheng
Li, Hua
Chen, Jiachun
author_sort Min, Qiuxia
collection PubMed
description The natural product mangiferin (compound 7) has been identified as a potential glucokinase activator by structure-based virtual ligand screening. It was proved by enzyme activation experiment and cell-based assays in vitro, with potency in micromolar range. Meanwhile, this compound showed good antihyperglycemic activity in db/db mice without obvious side effects such as excessive hypoglycaemia.
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spelling pubmed-53577922017-03-22 Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening Min, Qiuxia Cai, Xinpei Sun, Weiguang gao, Fei Li, Zhimei Zhang, Qian Wan, Luo-Sheng Li, Hua Chen, Jiachun Sci Rep Article The natural product mangiferin (compound 7) has been identified as a potential glucokinase activator by structure-based virtual ligand screening. It was proved by enzyme activation experiment and cell-based assays in vitro, with potency in micromolar range. Meanwhile, this compound showed good antihyperglycemic activity in db/db mice without obvious side effects such as excessive hypoglycaemia. Nature Publishing Group 2017-03-20 /pmc/articles/PMC5357792/ /pubmed/28317897 http://dx.doi.org/10.1038/srep44681 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Min, Qiuxia
Cai, Xinpei
Sun, Weiguang
gao, Fei
Li, Zhimei
Zhang, Qian
Wan, Luo-Sheng
Li, Hua
Chen, Jiachun
Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening
title Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening
title_full Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening
title_fullStr Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening
title_full_unstemmed Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening
title_short Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening
title_sort identification of mangiferin as a potential glucokinase activator by structure-based virtual ligand screening
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357792/
https://www.ncbi.nlm.nih.gov/pubmed/28317897
http://dx.doi.org/10.1038/srep44681
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