IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

T follicular regulatory (Tfr) cells control the magnitude and specificity of the germinal centre reaction, but how regulation is contained to ensure generation of high-affinity antibody is unknown. Here we show that this balance is maintained by the reciprocal influence of interleukin (IL)-2 and IL-...

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Detalles Bibliográficos
Autores principales: Jandl, Christoph, Liu, Sue M., Cañete, Pablo F., Warren, Joanna, Hughes, William E., Vogelzang, Alexis, Webster, Kylie, Craig, Maria E., Uzel, Gulbu, Dent, Alexander, Stepensky, Polina, Keller, Bärbel, Warnatz, Klaus, Sprent, Jonathan, King, Cecile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357862/
https://www.ncbi.nlm.nih.gov/pubmed/28303891
http://dx.doi.org/10.1038/ncomms14647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357862/
https://www.ncbi.nlm.nih.gov/pubmed/28303891
http://dx.doi.org/10.1038/ncomms14647

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