Cargando…

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

T follicular regulatory (Tfr) cells control the magnitude and specificity of the germinal centre reaction, but how regulation is contained to ensure generation of high-affinity antibody is unknown. Here we show that this balance is maintained by the reciprocal influence of interleukin (IL)-2 and IL-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jandl, Christoph, Liu, Sue M., Cañete, Pablo F., Warren, Joanna, Hughes, William E., Vogelzang, Alexis, Webster, Kylie, Craig, Maria E., Uzel, Gulbu, Dent, Alexander, Stepensky, Polina, Keller, Bärbel, Warnatz, Klaus, Sprent, Jonathan, King, Cecile
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357862/ https://www.ncbi.nlm.nih.gov/pubmed/28303891 http://dx.doi.org/10.1038/ncomms14647

Ejemplares similares

Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency
por: Cagdas, Deniz, et al.
Publicado: (2021)

IL-1β promotes IL-9-producing Th cell differentiation in IL-2-limiting conditions through the inhibition of BCL6
por: Canaria, D. Alejandro, et al.
Publicado: (2022)

Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models
por: McGuire, Helen M., et al.
Publicado: (2011)

Regulatory roles of IL-10–producing human follicular T cells
por: Cañete, Pablo F., et al.
Publicado: (2019)

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
por: Webster, Kylie E., et al.
Publicado: (2009)

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
por: Batten, Marcel, et al.
Publicado: (2010)

IFN-γ and IL-21 Double Producing T Cells Are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection
por: Carpio, Victor H., et al.
Publicado: (2015)

Evaluation of IL-3, IL-5, and IL-6 concentration in the follicular fluid of women with endometriosis: A cross-sectional study
por: Ghodsi, Mohammad, et al.
Publicado: (2022)

IL-6 of follicular fluid and outcome of in vitro fertilization
por: Stojanovic Gavrilovic, Aleksandra Z., et al.
Publicado: (2022)

IL-7 signalling represses Bcl-6 and the T(FH) gene program
por: McDonald, Paul W., et al.
Publicado: (2016)

Correction: IFN-γ and IL-21 Double Producing T Cells Are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection
por: Carpio, Victor H., et al.
Publicado: (2016)

Correction: IFN-γ and IL-21 Double Producing T Cells Are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection
por: Carpio, Victor H., et al.
Publicado: (2017)

IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells
por: Parvathaneni, Swetha, et al.
Publicado: (2023)

Overexpression of Interleukin (IL)-7 Leads to IL-15–independent Generation of Memory Phenotype CD8(+) T Cells
por: Kieper, William C., et al.
Publicado: (2002)

Batf is important for IL-4 expression in T follicular helper cells
por: Sahoo, Anupama, et al.
Publicado: (2015)

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8(+) Cells but Are Not Required for Memory Phenotype CD4(+) Cells
por: Tan, Joyce T., et al.
Publicado: (2002)

Antiviral CD4(+) memory T cells are IL-15 dependent
por: Purton, Jared F., et al.
Publicado: (2007)

Follicular Helper T Cells (Tfh) and IL-21 Involvement in the Pathogenesis of Bullous Pemphigoid
por: Li, Qiuju, et al.
Publicado: (2013)

Variation in IL-21-secreting circulating follicular helper T cells in Kawasaki disease
por: Xu, Meng, et al.
Publicado: (2018)

IL-7 and CD4 T Follicular Helper Cells in HIV-1 Infection
por: Chiodi, Francesca, et al.
Publicado: (2017)

Follicular regulatory T cells eliminate HIV-1-infected follicular helper T cells in an IL-2 concentration dependent manner
por: Ollerton, Matthew T., et al.
Publicado: (2022)

IL-21–Deficient T Follicular Helper Cells Support B Cell Responses Through IL-27 in Patients With Chronic Hepatitis B
por: Khanam, Arshi, et al.
Publicado: (2021)

Regulatory T cells provide chondroprotection through increased TIMP1, IL-10 and IL-4, but cannot mitigate the catabolic effects of IL-1β and IL-6 in a tri-culture model of osteoarthritis
por: Keller, Laura E., et al.
Publicado: (2021)

The Role of the IL-20 Subfamily in Glaucoma
por: Wirtz, Mary K., et al.
Publicado: (2016)

IL6 and BCL3 Expression Are Potential Biomarkers in Esophageal Squamous Cell Carcinoma
por: Soares-Lima, Sheila Coelho, et al.
Publicado: (2021)

The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases
por: Navarro-Compán, Victoria, et al.
Publicado: (2023)

T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma
por: Gong, Fang, et al.
Publicado: (2019)

T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21
por: Luo, Ran, et al.
Publicado: (2023)

Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome
por: Kotlarz, Daniel, et al.
Publicado: (2013)

The Emerging Role of the IL-17B/IL-17RB Pathway in Cancer
por: Bastid, Jérémy, et al.
Publicado: (2020)

Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era
por: Correia, Cristina, et al.
Publicado: (2023)

Protein Kinase C δ: a Gatekeeper of Immune Homeostasis
por: Salzer, Elisabeth, et al.
Publicado: (2016)

IL-4 and HDAC Inhibitors Suppress Cyclooxygenase-2 Expression in Human Follicular Dendritic Cells
por: Cho, Whajung, et al.
Publicado: (2013)

Human Lymphoid Stromal Cells Contribute to Polarization of Follicular T Cells Into IL-4 Secreting Cells
por: Misiak, Jan, et al.
Publicado: (2020)

Mucosal T follicular helper cells in SIV-infected rhesus macaques: contributing role of IL-27
por: Moukambi, Félicien, et al.
Publicado: (2019)

Survivin co-ordinates formation of follicular T-cells acting in synergy with Bcl-6
por: Andersson, Karin M.E., et al.
Publicado: (2015)

Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
por: Neves, Fabiana, et al.
Publicado: (2015)

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation
por: Eto, Danelle, et al.
Publicado: (2011)

Enhanced IL-6/phosphorylated STAT3 signaling is related to the imbalance of circulating T follicular helper/T follicular regulatory cells in patients with rheumatoid arthritis
por: Niu, Qian, et al.
Publicado: (2018)

IL-17A producing mast cells as therapeutic target in spondyloarthritis
por: Yeremenko, N, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_t6m0maqdn02mvfc739olt03nj0