An arginase‐1 SNP that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia enhances NO‐mediated apoptosis in lymphocytes

Arginase and nitric oxide synthase (NOS) share a common substrate, l‐arginine, and have opposing effects on vascular remodeling. Arginase is the first step in polyamine and proline synthesis necessary for cellular proliferation, while NO produced from NOS promotes apoptosis. Previously, we identifie...

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Detalles Bibliográficos
Autores principales: Trittmann, Jennifer K., Jin, Yi, Chicoine, Louis G., Liu, Yusen, Chen, Bernadette, Nelin, Leif D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358007/
https://www.ncbi.nlm.nih.gov/pubmed/27895230
http://dx.doi.org/10.14814/phy2.13041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358007/
https://www.ncbi.nlm.nih.gov/pubmed/27895230
http://dx.doi.org/10.14814/phy2.13041

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