Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations

G-quadruplexes (G4s) are higher-order DNA structures typically present at promoter regions of genes and telomeres. Here, the G4 formation decreases the replicative DNA at each cell cycle, finally leading to apoptosis. The ability to control this mitotic clock, particularly in cancer cells, is fascin...

Descripción completa

Detalles Bibliográficos
Autores principales: Moraca, Federica, Amato, Jussara, Ortuso, Francesco, Artese, Anna, Pagano, Bruno, Novellino, Ettore, Alcaro, Stefano, Parrinello, Michele, Limongelli, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358390/
https://www.ncbi.nlm.nih.gov/pubmed/28232513
http://dx.doi.org/10.1073/pnas.1612627114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358390/
https://www.ncbi.nlm.nih.gov/pubmed/28232513
http://dx.doi.org/10.1073/pnas.1612627114

Ejemplares similares