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6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis

The catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea tetramisole. An acidic workup proved necessary to minimize product epimerizatio...

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Detalles Bibliográficos
Autores principales:	Neyyappadath, Rifahath M., Cordes, David B., Slawin, Alexandra M. Z., Smith, Andrew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358503/ https://www.ncbi.nlm.nih.gov/pubmed/28133660 http://dx.doi.org/10.1039/c6cc10178j

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