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Optical control of AMPA receptors using a photoswitchable quinoxaline-2,3-dione antagonist

AMPA receptors respond to the neurotransmitter glutamate and play a critical role in excitatory neurotransmission. They have been implicated in several psychiatric disorders and have rich pharmacology. Antagonists of AMPA receptors have been explored as drugs and one has even reached the clinic. We...

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Detalles Bibliográficos
Autores principales: Barber, David M., Liu, Shu-An, Gottschling, Kevin, Sumser, Martin, Hollmann, Michael, Trauner, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358534/
https://www.ncbi.nlm.nih.gov/pubmed/28451208
http://dx.doi.org/10.1039/c6sc01621a