Acyclic quaternary centers from asymmetric conjugate addition of alkylzirconium reagents to linear trisubstituted enones

Synthetic methods for the selective formation of all carbon quaternary centres in non-cyclic systems are rare. Here we report highly enantioselective Cu-catalytic asymmetric conjugate addition of alkylzirconium species to twelve different acyclic trisubstituted enones. A variety of sp(3)-hybridized...

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Detalles Bibliográficos
Autores principales: Gao, Zhenbo, Fletcher, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358539/
https://www.ncbi.nlm.nih.gov/pubmed/28451211
http://dx.doi.org/10.1039/c6sc02811j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358539/
https://www.ncbi.nlm.nih.gov/pubmed/28451211
http://dx.doi.org/10.1039/c6sc02811j

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