ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells

Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we used derived cell lines and cells from patients to investigate how to overcome PARPi resistance. We found that the f...

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Detalles Bibliográficos
Autores principales: Yazinski, Stephanie A., Comaills, Valentine, Buisson, Rémi, Genois, Marie-Michelle, Nguyen, Hai Dang, Ho, Chu Kwen, Todorova Kwan, Tanya, Morris, Robert, Lauffer, Sam, Nussenzweig, André, Ramaswamy, Sridhar, Benes, Cyril H., Haber, Daniel A., Maheswaran, Shyamala, Birrer, Michael J., Zou, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358727/
https://www.ncbi.nlm.nih.gov/pubmed/28242626
http://dx.doi.org/10.1101/gad.290957.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358727/
https://www.ncbi.nlm.nih.gov/pubmed/28242626
http://dx.doi.org/10.1101/gad.290957.116

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