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ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells
Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we used derived cell lines and cells from patients to investigate how to overcome PARPi resistance. We found that the f...
Autores principales: | Yazinski, Stephanie A., Comaills, Valentine, Buisson, Rémi, Genois, Marie-Michelle, Nguyen, Hai Dang, Ho, Chu Kwen, Todorova Kwan, Tanya, Morris, Robert, Lauffer, Sam, Nussenzweig, André, Ramaswamy, Sridhar, Benes, Cyril H., Haber, Daniel A., Maheswaran, Shyamala, Birrer, Michael J., Zou, Lee |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358727/ https://www.ncbi.nlm.nih.gov/pubmed/28242626 http://dx.doi.org/10.1101/gad.290957.116 |
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