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Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expression
A critical role of circadian oscillators in orchestrating insulin secretion and islet gene transcription has been demonstrated recently. However, these studies focused on whole islets and did not explore the interplay between α-cell and β-cell clocks. We performed a parallel analysis of the molecula...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358758/ https://www.ncbi.nlm.nih.gov/pubmed/28275001 http://dx.doi.org/10.1101/gad.290379.116 |