Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons

Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is a key neuronal maintenance factor and provides potent neuroprotection in numerous preclinical models of neurological disorders. NMNAT2 is significantly reduced in Alzheimer’s, Huntington’s, Parkinson’s diseases. Here we developed a Meso...

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Detalles Bibliográficos
Autores principales: Ali, Yousuf O., Bradley, Gillian, Lu, Hui-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358788/
https://www.ncbi.nlm.nih.gov/pubmed/28266613
http://dx.doi.org/10.1038/srep43846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358788/
https://www.ncbi.nlm.nih.gov/pubmed/28266613
http://dx.doi.org/10.1038/srep43846

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