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Biophysical comparison of ATP-driven proton pumping mechanisms suggests a kinetic advantage for the rotary process depending on coupling ratio

ATP-driven proton pumps, which are critical to the operation of a cell, maintain cytosolic and organellar pH levels within a narrow functional range. These pumps employ two very different mechanisms: an elaborate rotary mechanism used by V-ATPase H(+) pumps, and a simpler alternating access mechanis...

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Detalles Bibliográficos
Autores principales: Anandakrishnan, Ramu, Zuckerman, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358804/
https://www.ncbi.nlm.nih.gov/pubmed/28319179
http://dx.doi.org/10.1371/journal.pone.0173500