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Evolving Notch polyQ tracts reveal possible solenoid interference elements
Polyglutamine (polyQ) tracts in regulatory proteins are extremely polymorphic. As functional elements under selection for length, triplet repeats are prone to DNA replication slippage and indel mutations. Many polyQ tracts are also embedded within intrinsically disordered domains, which are less con...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358852/ https://www.ncbi.nlm.nih.gov/pubmed/28319202 http://dx.doi.org/10.1371/journal.pone.0174253 |