An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP

Unfavorable redox conditions in the endoplasmic reticulum (ER) can decrease the capacity for protein secretion, altering vital cell functions. While systems to manage reductive stress are well-established, how cells cope with an overly oxidizing ER remains largely undefined. In previous work (Wang e...

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Detalles Bibliográficos
Autores principales: Siegenthaler, Kevin D, Pareja, Kristeen A, Wang, Jie, Sevier, Carolyn S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358974/
https://www.ncbi.nlm.nih.gov/pubmed/28257000
http://dx.doi.org/10.7554/eLife.24141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358974/
https://www.ncbi.nlm.nih.gov/pubmed/28257000
http://dx.doi.org/10.7554/eLife.24141

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