PDE11A negatively regulates lithium responsivity

Lithium responsivity in patients with bipolar disorder has been genetically associated with Phosphodiesterase 11A (PDE11A), and lithium decreases PDE11A mRNA in IPSC-derived hippocampal neurons originating from lithium responsive patients. PDE11 is an enzyme uniquely enriched in the hippocampus that...

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Detalles Bibliográficos
Autores principales: Pathak, G., Agostino, M.J., Bishara, K., Capell, W.R., Fisher, J.L., Hegde, S., Ibrahim, B.A., Pilarzyk, Kaitlyn, Sabin, C., Tuczkewycz, Taras, Wilson, Steven, Kelly, M.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359083/
https://www.ncbi.nlm.nih.gov/pubmed/27646265
http://dx.doi.org/10.1038/mp.2016.155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359083/
https://www.ncbi.nlm.nih.gov/pubmed/27646265
http://dx.doi.org/10.1038/mp.2016.155

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