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PDE11A negatively regulates lithium responsivity

Lithium responsivity in patients with bipolar disorder has been genetically associated with Phosphodiesterase 11A (PDE11A), and lithium decreases PDE11A mRNA in IPSC-derived hippocampal neurons originating from lithium responsive patients. PDE11 is an enzyme uniquely enriched in the hippocampus that...

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Detalles Bibliográficos
Autores principales:	Pathak, G., Agostino, M.J., Bishara, K., Capell, W.R., Fisher, J.L., Hegde, S., Ibrahim, B.A., Pilarzyk, Kaitlyn, Sabin, C., Tuczkewycz, Taras, Wilson, Steven, Kelly, M.P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359083/ https://www.ncbi.nlm.nih.gov/pubmed/27646265 http://dx.doi.org/10.1038/mp.2016.155

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