PGC-1α or FNDC5 Is Involved in Modulating the Effects of Aβ(1−42) Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting Neuronal Apoptosis, Aβ Deposition and Cognitive Decline of APP/PS1 Tg Mice

Alzheimer's disease (AD) is generally defined as the aberrant production of β-amyloid protein (Aβ) and hyperphosphorylated tau protein, which are deposited in β-amyloid plaques (APs) and neurofibrillary tangles (NFTs), respectively. Decreased levels of brain-derived neurotrophic factor (BDNF) h...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, De-Yu, Huang, Xin, Bi, Chong-Feng, Mao, Lin-Ling, Peng, Li-Jun, Qian, Hai-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359257/
https://www.ncbi.nlm.nih.gov/pubmed/28377712
http://dx.doi.org/10.3389/fnagi.2017.00065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359257/
https://www.ncbi.nlm.nih.gov/pubmed/28377712
http://dx.doi.org/10.3389/fnagi.2017.00065

Ejemplares similares