Human Cytochrome P450 3A4 as a Biocatalyst: Effects of the Engineered Linker in Modulation of Coupling Efficiency in 3A4-BMR Chimeras

Human liver cytochrome P450 3A4 is the main enzyme involved in drug metabolism. This makes it an attractive target for biocatalytic applications, such as the synthesis of pharmaceuticals and drug metabolites. However, its poor solubility, stability and low coupling have limited its application in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Degregorio, Danilo, D'Avino, Serena, Castrignanò, Silvia, Di Nardo, Giovanna, Sadeghi, Sheila J., Catucci, Gianluca, Gilardi, Gianfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359286/
https://www.ncbi.nlm.nih.gov/pubmed/28377716
http://dx.doi.org/10.3389/fphar.2017.00121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359286/
https://www.ncbi.nlm.nih.gov/pubmed/28377716
http://dx.doi.org/10.3389/fphar.2017.00121

Ejemplares similares