Can mutations in ELA2, neutrophil elastase expression or differential cell toxicity explain sulphasalazine-induced agranulocytosis?

BACKGROUND: Drug-induced agranulocytosis, a severe side effect marked by a deficit or absolute lack of granulocytic white blood cells, is a rare side-effect of the anti-inflammatory drug sulphasalazine. Mutations in the human neutrophil elastase gene (ELA2), causing increased intracellular concentra...

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Detalles Bibliográficos
Autores principales: Jacobson, Annica, Melhus, Håkan, Wadelius, Mia
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535939/
https://www.ncbi.nlm.nih.gov/pubmed/15575961
http://dx.doi.org/10.1186/1471-2326-4-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535939/
https://www.ncbi.nlm.nih.gov/pubmed/15575961
http://dx.doi.org/10.1186/1471-2326-4-5

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