Tissue Nonspecific Alkaline Phosphatase (TNAP) Regulates Cranial Base Growth and Synchondrosis Maturation

Hypophosphatasia is a rare heritable disorder caused by inactivating mutations in the gene (Alpl) that encodes tissue nonspecific alkaline phosphatase (TNAP). Hypophosphatasia with onset in infants and children can manifest as rickets. How TNAP deficiency leads to bone hypomineralization is well exp...

Descripción completa

Detalles Bibliográficos
Autores principales: Nam, Hwa K., Sharma, Monika, Liu, Jin, Hatch, Nan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359511/
https://www.ncbi.nlm.nih.gov/pubmed/28377728
http://dx.doi.org/10.3389/fphys.2017.00161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359511/
https://www.ncbi.nlm.nih.gov/pubmed/28377728
http://dx.doi.org/10.3389/fphys.2017.00161

Ejemplares similares