Electrostatic Switch Function in the Mechanism of Protein Kinase A Iα Activation: Results of the Molecular Dynamics Simulation

We used molecular dynamics to find the average path of the A-domain H → B conformational transition in protein kinase A Iα. We obtained thirteen productive trajectories and processed them sequentially using factor and cross-correlation analyses. The conformational transition is presented as partly d...

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Detalles Bibliográficos
Autores principales: Rogacheva, Olga N., Shchegolev, Boris F., Vershinina, Elena A., Tokmakov, Alexander A., Stefanov, Vasiliy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359514/
https://www.ncbi.nlm.nih.gov/pubmed/28367443
http://dx.doi.org/10.1155/2017/5846073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359514/
https://www.ncbi.nlm.nih.gov/pubmed/28367443
http://dx.doi.org/10.1155/2017/5846073

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