12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT

TPA stimulates carcinogenesis in various types of cancers. However, we found that TPA inhibits transformative phenotypes in liver cancer cells via the translocation of YAP from the nucleus, where it functions as a transcriptional co-factor, to the cytoplasm. Such effects led to a separation of YAP f...

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Detalles Bibliográficos
Autores principales: Zhu, Guoqing, Chen, Yan, Zhang, Xiao, Wu, Qi, Zhao, Yinghui, Chen, Yuxin, Sun, Fenyong, Qiao, Yongxia, Wang, Jiayi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359578/
https://www.ncbi.nlm.nih.gov/pubmed/28322318
http://dx.doi.org/10.1038/srep44940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359578/
https://www.ncbi.nlm.nih.gov/pubmed/28322318
http://dx.doi.org/10.1038/srep44940

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