12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT

TPA stimulates carcinogenesis in various types of cancers. However, we found that TPA inhibits transformative phenotypes in liver cancer cells via the translocation of YAP from the nucleus, where it functions as a transcriptional co-factor, to the cytoplasm. Such effects led to a separation of YAP f...

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Autores principales: Zhu, Guoqing, Chen, Yan, Zhang, Xiao, Wu, Qi, Zhao, Yinghui, Chen, Yuxin, Sun, Fenyong, Qiao, Yongxia, Wang, Jiayi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359578/
https://www.ncbi.nlm.nih.gov/pubmed/28322318
http://dx.doi.org/10.1038/srep44940
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author Zhu, Guoqing
Chen, Yan
Zhang, Xiao
Wu, Qi
Zhao, Yinghui
Chen, Yuxin
Sun, Fenyong
Qiao, Yongxia
Wang, Jiayi
author_facet Zhu, Guoqing
Chen, Yan
Zhang, Xiao
Wu, Qi
Zhao, Yinghui
Chen, Yuxin
Sun, Fenyong
Qiao, Yongxia
Wang, Jiayi
author_sort Zhu, Guoqing
collection PubMed
description TPA stimulates carcinogenesis in various types of cancers. However, we found that TPA inhibits transformative phenotypes in liver cancer cells via the translocation of YAP from the nucleus, where it functions as a transcriptional co-factor, to the cytoplasm. Such effects led to a separation of YAP from its dependent transcription factors. The inhibitory effects of TPA on YAP were AMOT dependent. Without AMOT, TPA was unable to alter YAP activity. Importantly, the depletion of YAP and AMOT blocked the TPA-reduced transformative phenotypes. In sum, TPA has been established as an anti-tumorigenic drug in liver cancer cells via YAP and AMOT.
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spelling pubmed-53595782017-03-22 12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT Zhu, Guoqing Chen, Yan Zhang, Xiao Wu, Qi Zhao, Yinghui Chen, Yuxin Sun, Fenyong Qiao, Yongxia Wang, Jiayi Sci Rep Article TPA stimulates carcinogenesis in various types of cancers. However, we found that TPA inhibits transformative phenotypes in liver cancer cells via the translocation of YAP from the nucleus, where it functions as a transcriptional co-factor, to the cytoplasm. Such effects led to a separation of YAP from its dependent transcription factors. The inhibitory effects of TPA on YAP were AMOT dependent. Without AMOT, TPA was unable to alter YAP activity. Importantly, the depletion of YAP and AMOT blocked the TPA-reduced transformative phenotypes. In sum, TPA has been established as an anti-tumorigenic drug in liver cancer cells via YAP and AMOT. Nature Publishing Group 2017-03-21 /pmc/articles/PMC5359578/ /pubmed/28322318 http://dx.doi.org/10.1038/srep44940 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhu, Guoqing
Chen, Yan
Zhang, Xiao
Wu, Qi
Zhao, Yinghui
Chen, Yuxin
Sun, Fenyong
Qiao, Yongxia
Wang, Jiayi
12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT
title 12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT
title_full 12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT
title_fullStr 12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT
title_full_unstemmed 12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT
title_short 12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT
title_sort 12-o-tetradecanoylphorbol-13-acetate (tpa) is anti-tumorigenic in liver cancer cells via inhibiting yap through amot
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359578/
https://www.ncbi.nlm.nih.gov/pubmed/28322318
http://dx.doi.org/10.1038/srep44940
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